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There are few interventions that help people with dementia retain or regain a sense of self. Thus, a controlled pilot study examined a life review/life storybook intervention, delivered by familiar care assistants to 30 people with dementia residing in assisted living facilities in Northern Ireland. A multivariate analysis of covariance showed significant change by group (F = 5.01, p < 0.014),...
The diagnosis of dementia, along with the prediction of who will develop dementia, has been assisted by the development of the brain imaging techniques of magnetic resonance imaging (MRI) and positron emission tomography (PET). This paper reviews the brain imaging technologies of structural MRI and PET scanning as they have been applied to both the diagnosis of dementia and prediction of who will...
Studies of dementia in populations avoid many of the selection biases in clinical samples but require special evaluation and diagnostic methods to obtain high participation rates. To address this issue, we developed a unique in-home dementia assessment. We assessed validity of these assessments using neuropathologic confirmation of the clinical diagnosis in 3 epidemiologic samples. Subjects were...
Early diagnosis and treatment of Alzheimer’s Disease (AD) ultimately will require identification of its pathogenic mechanism. Such a mechanism must explain the hallmark of early AD—a profound inability to form new memories. For many years, the most promising hypothesis maintained that memory failure derived from neuron death induced by insoluble deposits of amyloid fibrils. Newer findings, however,...
The Cognitive and Emotional Health Project (CEHP) seeks to identify the demographic, social, and biological determinants of cognitive and emotional health in the older adult. As part of the CEHP, a critical evaluation study committee was formed to assess the state of epidemiological research on demographic, social, and biological determinants of cognitive and emotional health. Criteria for inclusion...
The modified Telephone Interview for Cognitive Status (TICS-m) assesses cognitive status via the telephone and has been used to recruit for clinical trials by screening for amnestic mild cognitive impairment (aMCI). The utility of screening for aMCI has not been validated, and it is unknown which questions best predict aMCI. The Alzheimer’s Disease Cooperative Study (ADCS) used the TICS-m to recruit...
The question of whether to screen for dementia and Alzheimer’s disease (AD) has been discussed in many forums throughout the world. Generally, medical advisory groups and policy-making groups have recognized the importance of early diagnosis but have uniformly avoided making recommendations to screen at-risk populations. This presentation reflects the support for reconsidering the importance of screening...
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